GS-441524 tablets are a medication used to treat feline infectious peritonitis (FIP). This tablet can be taken orally directly, and it is recommended to take it with water on an empty stomach (at least 1 hour before meals or 2 hours after meals). During use, it is recommended to avoid combination with alkaline drugs such as aluminum sulfate tablets, aluminum hydroxide tablets, soda tablets, sodium bicarbonate tablets, and gastric relaxants. Do not take antacids, sucralfate, or polyphenols/supplements containing iron, zinc, magnesium, or aluminum within 2 hours of taking this product to prevent drug interactions and harm to cats.

GS-441524 Injection is an injection formulation containing GS-441524 as the active ingredient, typically a powder with high purity and stability. When using, specific solvents (such as 5% ethanol, 30% propylene glycol, 45% PEG 400, 20% water) are required, pH 1.5， Dilute with HCl to the desired concentration (such as 10 or 15 mg/ml) and place in a sterile glass injection bottle with stirring until suspended, then place in an ultrasonic water bath until clear. It acts as a competitor to natural triphosphate nucleosides in viral RNA synthesis, competing with natural nucleosides (ATP, TTP, CTP, GTP) to participate in RNA transcription. When GS-441524 molecule is inserted into the transcription product, transcription will terminate prematurely, thereby inhibiting the viral RNA transcription process and achieving antiviral effects.

GS-441524 fip is a highly effective drug for treating feline infectious peritonitis. This disease is a highly lethal feline disease caused by mutations in feline enterocoronavirus (FCOV). The characteristics of this disease are fluid accumulation in the body cavity, granulomatous vasculitis, and organ damage. Clinical manifestations include weight loss, loss of appetite, fever, jaundice, and ascites. Due to the lack of effective treatment methods, the prognosis of traditional treatment plans is extremely poor, and most sick cats die or are euthanized within a few months after diagnosis. It is mainly transmitted through fecal oral route. According to pathological manifestations, FIP can be divided into two types: exudative (wet) and non exudative (dry). The characteristic of wet FIP is fluid accumulation in the body cavity, while dry FIP is characterized by granulomatous vasculitis and organ damage.

GS-441524 powder is a high-purity and highly stable antiviral compound powder, which appears as a white or off white powder with a purity of usually ≥ 98%. It is soluble in dimethyl sulfoxide (DMSO) and needs to be diluted with specific solvents (such as ethanol, propylene glycol, PEG400 mixture) before use. It is an RNA dependent RNA polymerase (RdRp) inhibitor that disguises itself as a natural nucleotide, is recognized by the virus RdRp, and integrates into a newly synthesized RNA strand, causing strand termination and blocking virus replication. It is effective against coronaviruses such as SARS CoV, MERS CoV, and SARS-CoV-2, and has an EC50 value of 0.78 μ M against feline infectious peritonitis virus (FIPV), demonstrating strong inhibitory effects.